The 45-year-old Grey’s Anatomy star and the 46-year-old actress filed the paperwork on Friday (February 15) in Los Angeles, according to The Blast.
Eric and Rebecca got married back in 2004 after less than a year of dating.
The couple share two children – 7-year-old Billie and 6-year-old Georgia.
Rebecca is reportedly asking for joint legal and physical custody of the children as well as spousal support.
Eric and Rebecca have not yet released a statement about the news.